TMEM97 and cancer: Over the years, pharmacological, chemical, and biological papers have demonstrated that S2R is a potential therapeutic target for several diseases including neurodegenerative disorders and cancer (Vilner and Bowen, 1993; Vilner et al., 1995; Bowen, 2000; Wheeler et al., 2000; Crawford and Bowen, 2002; Kashiwagi et al., 2009; Hornick et al., 2010; Guo and Zhen, 2015).