SLC1A2 and Alzheimer disease: A recent study on post-mortem brains obtained from bodies of AD patients aged over 70 years at death showed that reactive astrocytes with enhanced glutamate transporter (GLT)-1 expression may protect neurons and synaptic transmission from the neurotoxicity due to Aβ and NFT deposition, and then help to maintain cognitive function despite the progression of AD neuro-pathological alterations (Kobayashi et al., 2018).