Nevertheless, several studies coincide on the crucial role played by microglial phagocytosis in the clearance of Tau and, consequently, in avoiding the spread of Tau and the progression of AD (Luo et al., 2015; Bolós et al., 2017c; Leyns and Holtzman, 2017; Figure 1). The gene discussed is MAPT; the disease is Alzheimer disease.