MAPT and tauopathy: In tauopathies, Tau which is a highly soluble hydrophilic protein, detaches from microtubules and accumulates, forming intracellular hyperphosphorylated aggregates or inclusions, such as the neurofibrillary tangles (NFTs) found in AD brains (Brion et al., 1985; Wood et al., 1986; Wischik et al., 1988; Zhang et al., 2009).