A growing body of evidence also indicates that ATP-mediated paracrine signaling in SCs is critical for the myelination process, which supports the hypothesis that alteration of Cx32 hemichannel opening and ATP release could underlie CMT1X (Nualart-Marti et al., 2013; Carrer et al., 2018). Here, GJB1 is linked to X-linked Charcot-Marie-Tooth disease type 1.