The top 25 most relevant variables comprised, besides baseline diagnosis (DX), results of different neuro-psychological/cognitive assessments (Alzheimer’s Disease Assessment Scale Cognitive Plus - ADAS13, ADAS11, Functional Assessment Questionnaire - FAQ, Clinical Dementia Rating - CDRSB, Rey Auditory Verbal Learning Test - RAVLT, Everyday Cognition Study Partner Report - EcogSPMem), neuro-imaging features (Region_Hippocampus, Region_Enthorhinal, Region_MidTemp, Region_WholeBrain8), PET and FDG PET imaging diagnosis (AV45, FDG), APOE4 status as well as patient age. This evidence concerns the gene APOE and early-onset autosomal dominant Alzheimer disease.