CASP3 and neoplasm: Further immunohistochemical analysis revealed that in contrast to the vehicle or single-agent-treated group, the tumors treated with combined GDC-0941/Aspirin, specifically in the non-necrotic tumor area, exhibited significantly reduced proliferation as determined by Ki67 staining positive cells and increased apoptosis as determined by cleaved-Caspase 3-positive cells (Fig. 5d).