TXN and tuberculosis: We and other groups previously found that 2-phenyl-1,2 benzisoselenazol-3(2H)-one (ebselen), is an effective compound against Gram-positive pathogens (including MDR mycobacteria tuberculosis) by targeting thioredoxin (Trx), which could transfer electrons from NADPH to their substrates via thioredoxin reductase (TrxR) that is critical for bacterial survival4,11,12.