IFN gene therapy in ALL mice induced ISGs at levels higher than those triggered in controls, (Fig. 4d and Supplementary Fig. 5a), and the transcriptomes of macrophages from control and IFN tumor-free mice showed high correlation, while they were clearly distinct from the ALL and IFN+ALL groups (Supplementary Fig. 5b). The gene discussed is IFNA1; the disease is acute lymphoblastic leukemia.