In the BM, leukemia induced a substantial depletion of myeloid cells (IFN + ALL vs CTRL + ALL: macrophages **p < 0.01, neutrophils *p < 0.05, non classical monocytes *p < 0.05, Kruskal–Wallis and Dunn correction), an effect not seen in IFN mice, which instead showed an increase in the number of DCs and in the fraction of DC presenting the immune-dominant OVA257–264 peptide on MHC-I (Fig. 3d, e and Supplementary Fig. 4c. This evidence concerns the gene IFNA1 and acute lymphoblastic leukemia.