Indeed, purified splenic CD4+ T cells from IFN+ALL mice showed significant up-regulation of Tbx21, encoding the Th1 transcription factor TBET, and Il17, a prototypical Th17 gene, while there were no changes in prototypical Th2 and Treg genes (Supplementary 8c. Here, TBX21 is linked to acute lymphoblastic leukemia.