In addition, in vivo tumorigenicity and metastasis studies on a highly metastatic AR-negative PC-3 subline PC-3M showed that ectopic T:E fusion expression in PC-3M cells could significantly promote their in vivo tumor growth and lymph node metastasis capacities in host SCID mice, as compared to their control counterpart PC-3M-vector/Luc+ infectants (Supplementary Fig. S10). The gene discussed is AR; the disease is neoplasm.