ESRRA and Familial prostate cancer: Results showed that a PCR product could be amplified in chromatin religated between promoter and enhancer (P6) regions of T:E fusion gene and the PCR signal was significantly suppressed in VCaP cells upon ERRα inhibition (XCT790) but not AR inhibition (siAR or enzalutamide) (Supplementary Fig. S7d), suggesting that ERRα could induce a promoter-enhancer DNA looping in transactivation of T:E fusion gene in prostate cancer cells.