HDAC8 and Buschke-Ollendorff syndrome: In particular, among the 23 most upregulated mRNAs in MSC from BOS patients (n = 3) respect to stable LTRs (n = 5), we identified two over-represented classes of epigenetic enzymes: histone deacetylases class I (HDAC1, HDAC2, HDAC3 and HDAC8) and methyltransferases (DNMT1, DNMT3B and EZH2).