Notably, our data are in line with previous findings of Sanders and coworkers29 that described an increase of de novo enzymes DNMT-3a and DNMT-3b in idiopathic pulmonary fibrosis (IPF) lungs, and of Dakhlallah et al. that reported DNMT1 expression increase in IPF lung tissues and lung fibroblast cell lines30, which is inversely correlated to FVC (forced expiratory vital capacity). Here, DNMT3A is linked to pulmonary fibrosis.