MIR100HG is highly expressed in acute megakaryoblastic leukemia (AMKL), with its knockdown shown to decrease AMKL cell proliferation and viability31, High expression of MIR100HG is also related to poor prognosis in early-stage cervical cancer34, and MIR100HG, miR-125b, and miR-100 are reportedly overexpressed in cetuximab-resistant colorectal cancer30. The gene discussed is MIR100HG; the disease is acute megakaryoblastic leukemia.