Nielsen et al. analyzed tumor and serum specimens obtained from patients with HGSC and found that the majority of CD20+ TILs were antigen experienced and suggested to accomplish TAA presentation in the TME since they often co-localized with CD8+ TILs and expressed markers such as MHC-I, MHC-II, CD40, CD80, and CD86 [108]. This evidence concerns the gene CD8A and neoplasm.