The results of the aforementioned studies led to the conclusion that inhibition of IL-1 signaling has a pronounced inhibitory effect on tumor growth by targeting different mechanisms of tumor development, such as: (i) reducing chronic inflammation which triggers tumor development; (ii) propagation of immune-suppressive cells; (iii) accumulation of regulatory cells in the tumor milieu; (iv) angiogenesis; and (v) metastasis. Here, IL1A is linked to neoplasm.