We found decreased expressions of FAK, p-PI3K, p-Akt, and p-mTOR in A2058 and A375 cells after bornyl cis-4-hydroxycinnamate treatment, which suggested involvement of the FAK/PI3K/Akt/mTOR signaling pathways in the inhibitory effects of bornyl cis-4-hydroxycinnamate in malignant melanoma cells. This evidence concerns the gene AKT1 and melanoma.