It can be seen that the risk of bladder cancer progression decreased with the homozygous genotype “WW” of COMT (HR = 0.482; 95%CI = 0.259 to 0.899; p = 0.022) and the homozygous genotype “WW” of MnSOD (HR = 0.446; 95%CI = 0.212 to 0.936; p = 0.033). The gene discussed is SOD2; the disease is urinary bladder cancer.