Nramp1+/+ (Nramp1G169) and Nramp1+/− (NrampG169/D169) mice are ~1000-fold more resistant to S. Typhimurium infection, compared to the Nramp1−/− counterpart, and therefore serves as a chronic Salmonella infection model [45,46]. The gene discussed is SLC11A1; the disease is Salmonella Infections.