In order to differentiate whether KLF2 and p21 were also involved in SNHG3-mediated tumorigenesis in glioma, we examined the expressions of KLF2 and p21 in glioma tissues, exposing that both of the expressions of KLF2 and p21 were down-regulated in glioma tissues, in comparison with the normal ones (Figure 4A). Here, SNHG3 is linked to central nervous system cancer.