Although multiple genes have been reported to be capable of interacting with KLF2 and p21, such as GHET1 and KLF2 in hepatocellular carcinoma [28], SNHG15 and KLF2 in pancreatic cancer [29], HOXA-AS2, p21 and KLF2 in colorectal cancer [15], the interaction among SNHG3, KLF2 and p21 is still masked. Here, KLF2 is linked to colorectal cancer.