Retroperitoneal lymph node metastases were present in more than 10% of cases at PSA levels of greater than or equal to 0.5 ng/mL (12.8% [6/47], 11.1% [6/54], and 39.3% [33/84] at PSA levels of 0.5–<1, 1–<2, and ≥2 ng/mL, respectively). The gene discussed is KLK3; the disease is metastatic malignant neoplasm in the lymph nodes.