NFKB1 and neoplasm: In addition, to further verify that miR-22/KAT6B functions in the chemotherapy resistance through the AKT-NF-κB pathway, we selected the heterotopic tumor tissue obtained from the previous animal experiment, which were fixed by formaldehyde, paraffin embedded, continuous sliced and tested for the immunization of KAT6B and AKT signaling molecules.