Based on this information, we postulate a likely mechanism of intra-tumor recruitment of M1-like macrophages and IL12-activated NK cells (Additional file 12: Figure S12) in which CCP-induced MCP-1 release from TAM initiates the process of macrophage activation, intra-tumor recruitment, NK cell activation by macrophage-released IL12, and MCP-1-evoked recruitment of activated NK cells into GBM. The gene discussed is CCL2; the disease is neoplasm.