APOE and Alzheimer disease: The AD+APOE GRS was also strongly associated with both amyloid (4.7 × 10− 21 > Puncor > 1.8 × 10− 23) and tau (7.1 × 10− 20 > Puncor > 1.2 × 10− 22) phenotypes; whereas the AD-APOE GRS was only associated with tau measures (5.5 × 10− 4 > Puncor > 5.5 × 10− 4) (Fig. 2).