After FDR correction, both the AD GRS including (AD+APOE) and excluding (AD-APOE) the APOE ɛ4 risk haplotype were significantly associated with faster decline in all cognitive domains proximal to death (min Puncor < 1 × 10− 16), but no other GRS demonstrated significant associations (Fig. 1). Here, APOE is linked to Alzheimer disease.