MAPT and Alzheimer disease: Several GRS tested showed effects in the directions expected based on existing literature: both the AD+APOE and AD-APOE GRS were significantly associated with cognitive decline at corrected thresholds, but, interestingly, the AD-APOE GRS was only significantly associated with tau-related neuropathology, complimenting existing evidence from in vivo PET imaging and CSF analyses showing an effect of APOE ε4 on amyloid- but not tau-related biomarkers in healthy elderly [35].