HPGDS and type 2 diabetes mellitus: To know whether cytotoxic action of STZ on RIN5F cells is due to changes in the concentrations of various anti-oxidants, we studied the activity of SOD, catalase, glutathione S-transferase, glutathione peroxidase (Fig. 2) and alterations in lipid peroxides and nitric oxide (Fig. 3) in these cells and pancreas of STZ-induced type 2 diabetes animals (Table 1).