INS and type 2 diabetes mellitus: Based on a previous study, freeze-dried aronia, red ginseng, ultraviolet-irradiated shiitake mushroom and nattokinase were mixed at the ratio of 3.4:4.1:2.5:0.1 and the anti-diabetic activity was examined by assessing its efficacy for improving insulin sensitivity and potentiating insulin secretion in non-obese type 2 diabetic rats (Px rats).