In the case of gene expression signatures in smoking versus never smoking for stage 1 HNSCC patients, using the PantherDB online tool we observed an important number of representative transcripts that are responsible for biological adhesion, including for early stages (DLL3, CDH17, TINAGL1, STRC, PCDHAC2, PCDHB13, TNR, PCDHGB6, PCDHGA9, PLXNB3). The gene discussed is DLL3; the disease is head and neck squamous cell carcinoma.