Pathway enrichment analysis indicates that the transforming growth factor (TGF)-beta signaling pathway, the regulation of lipolysis in adipocytes, the extracellular matrix (ECM)-receptor interaction, the phosphoinositide 3-kinase (PI3K)-protein kinase B (Akt) signaling pathway, hypertrophic cardiomyopathy (HCM), and the biosynthesis of unsaturated fatty acids related to heart failure were altered. This evidence concerns the gene AKT1 and heart failure.