Notably, S100A4 secretion by fibroblasts has been shown to be stimulated by co-culture with tumor cells in vitro [8], and IL-1β-expressing cancer cells showed a dramatic increase of S100A4 in the stroma adjacent to skeletal metastases, that promoting early colonization of prostate cancer in vivo [9]. This evidence concerns the gene S100A4 and Familial prostate cancer.