GJB2 and head and neck squamous cell carcinoma: In the present study, to define the roles of connexin protein localised in a Golgi area in the malignant phenotype of human head and neck squamous cell carcinoma (HNSCC), we transduced human FaDu hypopharyngeal cancer cells with the retrovirus vector carrying the mutant Cx26 cDNA which encoded intracellular Cx26 (icCx26) protein and compared their cancerous behaviours with those of the clones transduced with the wild-type Cx26 (wtCx26) or the empty vector.