BRCA2 and cancer: Among the pathogenic mutations, 21 (21/40, 52.5%) were detected in BRCA1 and 19 (19/40, 47.5%) were detected in BRCA2. The age at the time of the cancer diagnosis was about 5 years lower in carriers of BRCA1 pathogenic mutations (mean, 46.3 y; median, 46 y; range, 31–77 y) than in BRCA2 pathogenic mutation carriers (mean 49.6 y; median, 51 y; range, 32–65 y).