At least four VUS in BRCA2 (p.G3076E, p.Y3092C, p.R2336H, and p.N3124I) showed very similar results to the p.C61G founder mutation in BRCA1. Interestingly, two of these mutations (p.N3124I and p.R2336H) were detected in subjects (see above) from families with multiple cases of breast or ovarian cancer and breast cancer (S3 Table). The gene discussed is BRCA1; the disease is breast carcinoma.