We think that the modifying effects of other genes or factors [3,89] and any other accompanying neutropenia mutations [87] and many other factors that play roles in the transmission of disease, including the 159T>C polymorphism in the same exon of HAX1 mutation in patients with HAX1 and other mutations as in other cases [90,91], both in the patients and parents, need to be evaluated in further studies. Here, HAX1 is linked to neutropenia.