It was reported that METTL3 exerted tumour promoter function in the development of AML with the methylation catalytic activity.92, 93 Knockdown of METTL3 led to a proliferation defect in AML cells, whereas overexpression of METTL3 rescued the proliferation defect, but inhibited myeloid differentiation of haematopoietic stem/progenitor cells (HSPCs).92, 93 Further investigations showed that the expression patterns of METTL3 and METTL14 were much more abundant in AML cell lines. Here, METTL14 is linked to acute myeloid leukemia.