ALKBH5 and acute myeloid leukemia: A global view depicts that mutations of m6A regulatory genes were identified in 2.6% of AML, 2.4% of multiple myeloma and 1.0% of acute lymphoblastic leukaemia.85 It was also observed that copy number variations (CNVs) appeared in 10.5% of AML patients, among which copy number loss of ALKBH5 was the most frequent.