HBXIP is commonly identified as an oncogene and exerts a profound effect on breast cancer.89, 90 A recent study has found that there was a strongly positive association between HBXIP and METTL3.91 Overexpression of HBXIP could significantly elevate the expression of METTL3 in breast cancer tissues and vice versa. The gene discussed is METTL3; the disease is breast carcinoma.