CD4 and neoplasm: In addition, IFNγ induces a number of signals in T cells to enable T cell function effectively, while the loss of IFNγ signaling pathways in T cells dampens T cell responses and allows tumor growth and persistence.29 On the other hand, IFNγ signaling also promotes tumor elimination by inhibiting the functions of some suppressive immune cells in the tumors, such as regulatory CD4+ T cells (Tregs),30 myeloid‐derived suppressor cells (MDSCs)31 and tumor‐associated macrophages (TAMs).