In addition, IFNγ treatment of gastric tumor cell lines followed by PD‐L1 antibody results in enhancing antitumor CTL activity.46 Moreover, in clinical gastric cancer samples, PD‐L1 expression on tumor cells is significantly associated with IFNγ expression in the tumor and the proportion of CD8+ T cells in the stroma.46 These findings imply that gastric cancer patients with high CD8+ T‐cell infiltration and intratumoral IFNγ expression may be more responsive to PD‐L1 inhibitor therapy. This evidence concerns the gene IFNG and gastric cancer.