Twist1 negatively regulates IFNγ expression.12 Mechanistically, Twist1 can form a complex with runt‐related transcription factor 3 (Runx3) to reduce the binding of Runx3 and T‐bet to Ifng locus, which resultantly suppresses IFNγ expression.12 In a mouse model of sporadic colon cancer, IL‐33 treatment induces IFNγ secretion by tumor allograft‐infiltrating T cells and the deficiency of its receptor ST2 within the nonhematopoietic cells resulted in a reduced IFNγ gene expression signature.13 However, the mechanism underlying IL‐33‐induced IFNγ expression is needed to investigate. The gene discussed is TWIST1; the disease is malignant colon neoplasm.