MUC16 (also known as CA125) is a high molecular weight trans‐membrane mucin, a well‐known biomarker for human cancers.37, 38 MUC16 contributes to tumor development through multiple different mechanisms, such as suppressing NK cell killing capacity, reducing the sensitivity of cancer cells to drug therapy, and promoting cancer cell motility and so on.38 Morgado et al37 showed that IFNγ plus TNFα resulted in upregulation of MUC16 mRNA and protein in a wide spectrum of cancer cell types, but not alone, implying that this may be a general response. This evidence concerns the gene IFNG and cancer.