IFNG and ovarian cancer: Lu et al41 showed that IFNγ/STAT1 signaling pathways suppressed TNFSF15 expression in human umbilical vein endothelial cells and TNFSF15 expression diminished while tumor vascularity increased in ovarian cancer clinical specimens with high levels of IFNγ expression.41 This finding indicates that IFNγ produced by tumor microenvironments inhibits TNFSF15 expression in vascular endothelial cells, leading to angiogenesis in the tumors.