Monocytes‐derived TAMs are the M2‐polarized macrophages in most human tumors, which secrete a large amount of vascular endothelial growth factor (VEGF) to promote tumor growth.33 IFNγ can suppress the differentiation of monocyte‐derived TAMs in the tumor microenvironments and furthermore switch TAMs from M2 into M1 macrophages, which suppress VEGF secretion in vitro and in vivo and thereby inhibit angiogenesis. The gene discussed is VEGFA; the disease is neoplasm.