Inhibition of TUG1 inhibited CRC cell proliferation, migration, and EMT.29 The AKT/mTOR signaling is a pivotal pathway participating in multiple physiological and pathological processes, including gene transcription, protein translation, cell cycle regulation, and proliferation.30 CRNDE is involved in the cell proliferation, migration, and invasion of CRC cells by increasing expression of TCF7L2 and activity of Wnt‐β‐catenin signaling through competitive binding to miR‐217.31 lncRNAs are crucial factors for tumor occurrence and development and require further study. The gene discussed is CRNDE; the disease is colorectal carcinoma.