REG1A and cancer: Regenerating gene (REG) I plays key roles in cancer cell biology,14 which has not been reported for CRC but has for squamous esophageal cancer 14 and head and neck squamous cell carcinoma.15 There are reports that the REG family is composed of antiapoptotic factors and growth factors in the digestive system,15 and all REG family mRNAs are upregulated in inflammatory bowel disease.16 REG expression is higher in CRC, and REG therefore may be a potential marker.