In a pool analysis of four studies that used urinary creatinine-adjusted data [118, 132, 150, 151], the sensitivity for the early diagnostic capacity of urinary cystatin C was 0.52, the specificity was 0.70, and the AUC was 0.64 (95% CI 0.62–0.66); therefore, the diagnostic accuracy was low, indicating that the urinary cystatin C is of limited utility for the early diagnosis of AKI. This evidence concerns the gene CST3 and acute kidney injury.