However, the clinical studies related to the present CQ raised several issues about the clinical application of the urinary NGAL, including the following: some studies did not use officially approved measurement methods; multiple measurement methods were used, and they were not standardized; there was no set cutoff value; urinary tract infections and urologic diseases increase the urinary NGAL levels [141]; and there are very few relevant clinical studies of Japanese subjects. Here, LCN2 is linked to urinary tract infection.