Fortunately, a subgroup of grade II-IV astrocytoma patients with oxygen 6-methylguanine-DNA methyltransferase (MGMT) promoter methylation show good responses to temozolomide (TMZ) chemotherapy and improved survival after treatment, which underscored the role of MGMT as a judicious molecular biomarker with a prognostic implication [4–7]. This evidence concerns the gene MGMT and astrocytoma (excluding glioblastoma).