ESR1 and carcinoma: Histopathological finding of the excised lesion showed microscopically a infiltrative carcinoma compatible with breast origin (Fig. 3) based on immunohistochemical study result that was positive for Estrogen Receptor (ER), Cytokeratin 7 and E-cadherin (Fig. 4) but negative for C-Erb-b2 and Progesterone receptor (PR).