ERBB2 and neoplasm: In addition, the modulated ECM can serve as a reservoir for oncogenic signals,40–42 which may influence CSC properties including migration and drug resistance.43–45 Breast CAFs isolated from HER2-positive, triple-negative, and ER-positive breast tumors showed distinct gene expression patterns and functions.46 This study showed that properties of CAFs are highly influenced by the adjacent cancer cells and it also supports the tumor-stroma co-evolution hypothesis, which suggests that CAFs can fine tune their supporting role to the specific tumor cells.46