To further assess the sensitivity of the imaging tools, we treated half the animals with daily oral dosing of pioglitazone, a peroxisome proliferator-activated receptor gamma (PPARγ) agonist known to modulate the expression of genes involved in the cellular response to oxidative stress and inflammation.26 Our overall aim was to develop methods for in vivo visualization of mechanisms of neurodegeneration and target validation of potential therapeutics for PD cardiac dysautonomia. Here, PPARG is linked to Parkinson disease.