We previously showed that: (i) LonP1 is upregulated in several cancer cell lines, including RKO, and in CRC tissues if compared to adjacent normal mucosa, and that (ii) colon cancer cells with low levels of LonP1 displayed reduced levels of OXPHOS complexes, reduced OCR, and increased mitochondrial ROS and highly fragmented and altered mitochondria (22). Here, LONP1 is linked to malignant colon neoplasm.