It has been recognized that bioactive oxPLs attenuate the effects of several osteogenic factors, such as BMPs, Wnt, and PTH in mice and humans with hyperlipidemia.32,43,52 Consistent with these observations, we detected inhibited signaling transduction of PTH, Wnt, and BMP after treatment with oxPLs. This evidence concerns the gene PTH and hyperlipidemia.