We then examined whether cell surface LRP6 level in MSCs could be restored by treating the HFD mice with D-4F, an apolipoprotein A-I mimetic peptide that scavenges ROS and suppresses the production of lipid peroxide.42,43 Indeed, D-4F increased the percentage of LRP6+ cells in bone marrow LepR+CD45–CD31–Ter119– MSCs in HFD-fed mice to a similar level as in CHD mice (Fig. 1m–o). The gene discussed is PECAM1; the disease is coronary artery disorder.