We performed flow cytometry analysis of LRP6 expression in bone marrow LepR+CD45–CD31–Ter119– cells, which are recognized as multipotent MSCs in adult bone marrow.36,37 The percentage of LRP6+ cells was markedly decreased in the LepR+CD45–CD31–Ter119– cell population (Fig. 1e and left panel in Fig. 1f) but not in CD11b+ macrophages (Fig. 1g and left panel in Fig. 1h) in bone marrow from HFD-fed mice compared with that of CHD-fed mice. The gene discussed is ITGAM; the disease is coronary artery disorder.