TLR4 and atherosclerosis: Whereas native LDL (nLDL) binds to the LDL receptor (LDLR), oxLDL and individual oxPLs bind to several scavenger receptors (SRs), including CD36,25 SR-A,26 and -B,27 the lectin-like oxidized-(LDLR 1 (LOX-1),28 and Toll-like receptor 4 (TLR-4)29 for the uptake of oxLDL by macrophages and vascular cells to facilitate atherosclerosis development.30 It has been recognized that the same oxPLs that promote atherosclerosis also act on bone to exert their detrimental effect.1,31–33 However, the major molecular targets of bioactive oxPLs for their adverse effect on bone cells remain elusive.