Mroczko et al. [82] studied the diagnostic applicability of IL-6 in differentiating between pancreatic cancer and chronic pancreatitis and found that the AUC was higher for serum IL-6 (AUC 0.94) than serum CA 19.9 (AUC 0.86), CEA (AUC 0.89) and CRP (AUC 0.84). This evidence concerns the gene CEACAM5 and familial pancreatic carcinoma.