Groblewska et al. [24] demonstrated that IL-6 levels were significantly higher in colorectal cancer patients than in colorectal adenoma patients and healthy controls, and IL-6 levels proved to be a better diagnostic marker (AUC 0.90) than CEA (AUC 0.79), CRP (AUC 0.82) and CA 19.9 (AUC 0.65). This evidence concerns the gene IL6 and colorectal adenoma.