IL6 and cancer: Ying et al. [78] showed that IL-6 plays a pivotal role in the development of cancer stem cells in colorectal cancer and that anti-IL-6-antibody significantly increased chemo sensibility, and Cross-Knorr et al. [13] showed that apoptosis of murine colorectal cancer cells induced by oxaliplatin was lowered from 32% to 19% when colorectal cancer cells were co-treated with IL-6.