However, the spheroids formed by TRAF3IP2-silenced U87 cells (U87TRAF3IP2KDversus U87control shRNA cells) expressed markedly reduced VEGF, IL-17R, IL-1β, IL-6, and IL-8 expression (Figure 3G), further demonstrating a pro-angiogenic and pro-inflammatory role of TRAF3IP2 in glioblastoma cells. This evidence concerns the gene IL1B and glioblastoma.