In addition to the requirement of GRP78 for tumor progression and for cancer cell proliferation, tumor-associated endothelial cells also express a high level of GRP78 compared to endothelial cells of normal organs, and GRP78 is required for neoangiogenesis during tumor growth as well as chemoresistance of tumor-associated endothelial cells [12, 13]. The gene discussed is HSPA5; the disease is neoplasm.