HSPA5 and lung carcinoma: However, in A549 lung cancer cells, IT-139 has no effect on GRP78 mRNA, but moderately elevates its protein level in non-stressed cells and stress induction of GRP78 mRNA was not affected, but GRP78 protein level was suppressed, implying that IT-139 suppresses GRP78 stress-induced expression at the post-transcriptional level in these cells.