Further dose response analyses with reference to A549 and H1299 NSCLC cells (Figure 1A) and other NSCLC cells with mutant EGFR (see below) revealed that GI50 and LC50 of CFM-4.16 were 2.0 μM and 5–5.8 μM respectively (not shown). This evidence concerns the gene EGFR and non-small cell lung carcinoma.