KLF5 and precursor B-cell acute lymphoblastic leukemia: In our data set, we found that GSTM1, a critical enzyme involved in the detoxification process of oxidative species and associated with poor-prognosis pediatric B-ALL [50–54], is a direct transcriptional target of KLF5 and is decreased in Klf5∆/∆ B-cell precursors.