KLF5 and cancer: In addition, an analysis of a genome-scale shRNA screen of 501 cancer cell lines, revealed that five non-BCR-ABL B-ALL cell lines are not enriched for a dependency on KLF5, indicating that KLF5 does not score as an oncogenic- or tumor suppressor-dependency for non-BCR-ABL B-ALL (Supplementary Figure 1B) [20].