To define the oncogenic function of LMO1 in lung cancers, we investigated the regulation of cell survival and proliferation by LMO1 in a panel of lung cancer cell lines that were derived from different histological subtypes of lung cancer, including adenocarcinoma, squamous cell carcinoma, small cell lung carcinoma, and large cell neuroendocrine lung carcinoma. This evidence concerns the gene LMO1 and small cell lung carcinoma.