The regulation of FANCD2 by mTOR has been also shown in rhabdomyosarcoma xenografts, where treatment by the dual mTOR inhibitor AZD8055 significantly enhanced radiosensitivity and melphalan through a downregulation of FANCD2 expression, suggesting that mTOR may promote the repair of DNA double-strand breaks by sustaining FANCD2 [29]. The gene discussed is FANCD2; the disease is rhabdomyosarcoma.