FANCD2 protein belongs to the Fanconi Anemia Pathway and is required for repair of DSB and intra-S-phase checkpoint activation [14], while SUV39H1 is a methyltransferase that directs H3K9 methylation on large chromatin domains adjacent to the DSB to promote activation of DSB-signaling proteins [15]. This evidence concerns the gene SUV39H1 and Fanconi anemia.