In GBMs with no copy number aberration in INK4b-ARF-INK4a locus, we found upregulation of all genes that are present in the locus -ANRIL, CDKN2A and CDKN2B thus signifying the absence of ANRIL-mediated repression of INK4b-ARF-INK4a locus in GBM. The gene discussed is CDKN2A; the disease is glioblastoma.