In GBMs with no copy number aberration in INK4b-ARF-INK4a locus, we found upregulation of all genes that are present in the locus -ANRIL, CDKN2A and CDKN2B thus signifying the absence of ANRIL-mediated repression of INK4b-ARF-INK4a locus in GBM. This evidence concerns the gene CDKN2B-AS1 and glioblastoma.