Genes that modulate apoptosis were similarly enriched in Lean- and MetS-EVs, but further analysis showed that those enriched in Lean-EVs encoded anti-apoptotic proteins, such as CFLAR (CASP8 and FADD-like apoptosis regulator) and heat-shock-related 70-kDa protein-2 (HSPA2). This evidence concerns the gene CFLAR and metabolic syndrome.