Contrarily, genes enriched in MetS-EVs encode proteins involved in translation elongation and ribonucleoprotein complex (Fig. 2b), including (Fig. 1c) eukaryotic translation initiation factor-2 subunit-alpha (EIF2S1), eukaryotic translation initiation factor 5B (EIF5B), ribosomal protein S17 (RPS17), and ribosomal protein (RP)-L6, 7, 10, 14. Here, BLOC1S3 is linked to metabolic syndrome.