Other pro-inflammatory genes enriched in MetS-EVs (Fig. 1c) included the phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (PIK3CB) [41] and several members of the ubiquitin-proteasome pathway involved in development of inflammatory and autoimmune diseases [42]. This evidence concerns the gene PIK3CB and autoimmune disease.