Interestingly, the lack of eATP-mediated infection control after pharmacological P2Y2 inhibition shows that the effects of eUTP and eATP are both initiate and dependent on P2Y2-signaling, suggesting that receptor activation by distinct DAMPs (UTP and ATP) is required to reduce L. amazonensis load in macrophages (Figure 2). Here, P2RY2 is linked to infection.