The amplification of T- and B-cell clusters throughout the parenchyma in the HLA-DRB1*03+ sarcoid lung, where granulomas were not always evident, suggests the more numerous CD20+ B-cells to predominantly serve an antigen-presenting function in a local transient inflammation within the inducible bronchus-associated lymphoid tissue. Here, HLA-DRB1 is linked to Granuloma.